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rarb antagonist le135  (Tocris)


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    Tocris rarb antagonist le135
    FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM <t>LE135</t> (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.
    Rarb Antagonist Le135, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 66 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rarb+antagonist+le135/LE+135/pm29677354-37-26-29
    Average 92 stars, based on 66 article reviews
    rarb antagonist le135 - by Bioz Stars, 2026-09
    92/100 stars

    Images

    1) Product Images from "Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish."

    Article Title: Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish.

    Journal: Investigative ophthalmology & visual science

    doi: 10.1167/iovs.17-22845

    FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM LE135 (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.
    Figure Legend Snippet: FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM LE135 (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.

    Techniques Used: Activity Assay, Inhibition, Control

    Related Articles

    Activity Assay:

    Article Title: Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish.
    Article Snippet: All-trans RA (Sigma-Aldrich Corp., St. Louis, MO, USA), 4- diethylaminobenzaldehyde (DEAB; Sigma-Aldrich Corp.), the retinoic acid receptor (RAR)a antagonist BMS195614 (Tocris Biosciences, Avonmouth, Bristol, UK), the RARb antagonist LE135 (Tocris Biosciences), and the RARc antagonist MM11253 (Tocris Biosciences) were diluted to 10003 treatment concentrations in dimethylsulfoxide (DMSO; Sigma-Aldrich Corp.) and added into reverse osmosis system fish water at 13 final concentrations.. Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and 0.1, 1, and 10 nM MM11253), and the final concentrations were selected by the LD50 and consistency of phenotype (data not shown).Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and..

    Inhibition:

    Article Title: Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish.
    Article Snippet: All-trans RA (Sigma-Aldrich Corp., St. Louis, MO, USA), 4- diethylaminobenzaldehyde (DEAB; Sigma-Aldrich Corp.), the retinoic acid receptor (RAR)a antagonist BMS195614 (Tocris Biosciences, Avonmouth, Bristol, UK), the RARb antagonist LE135 (Tocris Biosciences), and the RARc antagonist MM11253 (Tocris Biosciences) were diluted to 10003 treatment concentrations in dimethylsulfoxide (DMSO; Sigma-Aldrich Corp.) and added into reverse osmosis system fish water at 13 final concentrations.. Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and 0.1, 1, and 10 nM MM11253), and the final concentrations were selected by the LD50 and consistency of phenotype (data not shown).Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and..

    Control:

    Article Title: Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish.
    Article Snippet: All-trans RA (Sigma-Aldrich Corp., St. Louis, MO, USA), 4- diethylaminobenzaldehyde (DEAB; Sigma-Aldrich Corp.), the retinoic acid receptor (RAR)a antagonist BMS195614 (Tocris Biosciences, Avonmouth, Bristol, UK), the RARb antagonist LE135 (Tocris Biosciences), and the RARc antagonist MM11253 (Tocris Biosciences) were diluted to 10003 treatment concentrations in dimethylsulfoxide (DMSO; Sigma-Aldrich Corp.) and added into reverse osmosis system fish water at 13 final concentrations.. Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and 0.1, 1, and 10 nM MM11253), and the final concentrations were selected by the LD50 and consistency of phenotype (data not shown).Dose curves were conducted for each pharmacologic treatment (10, 25, and 100 nM RA; 5, 10, and 15 lM DEAB; 1 and 10 lM BMS195614; 0.1, 1, and 10 lM LE135; and..



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    FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM <t>LE135</t> (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.
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    FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM <t>LE135</t> (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.
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    Image Search Results


    FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM LE135 (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.

    Journal: Investigative ophthalmology & visual science

    Article Title: Retinoic Acid Maintains Function of Neural Crest-Derived Ocular and Craniofacial Structures in Adult Zebrafish.

    doi: 10.1167/iovs.17-22845

    Figure Lengend Snippet: FIGURE 4. RARc mediates RA activity in the adult zebrafish eye. Quantitative measurement of fluorescence intensity in eyes of Casper Tg(rare:mCherry) fish showed that inhibition of RA synthesis by 10 lM DEAB (16.5 6 1.7) or treatment with the RARc antagonist MM11253 at 10 nM (11.9 6 2.7) significantly decreased mCherry signal as compared to untreated (30.5 6 4.4) or 0.1% DMSO control–treated fish (26.9 61.0). Treatment with 100 nM RA (25.5 6 1.1), 1 lM BMS195614 (24.4 6 4.9), or 1 lM LE135 (27.3 6 3.1) did not significantly alter mCherry signal intensity. There was minimal to no fluorescence signal in Casper fish, which do not carry the transgene (1.5 6 1.5). (a) P < 0.01. (b) P < 0.001. (c) P < 0.0001.

    Article Snippet: All-trans RA (Sigma-Aldrich Corp., St. Louis, MO, USA), 4- diethylaminobenzaldehyde (DEAB; Sigma-Aldrich Corp.), the retinoic acid receptor (RAR)a antagonist BMS195614 (Tocris Biosciences, Avonmouth, Bristol, UK), the RARb antagonist LE135 (Tocris Biosciences), and the RARc antagonist MM11253 (Tocris Biosciences) were diluted to 10003 treatment concentrations in dimethylsulfoxide (DMSO; Sigma-Aldrich Corp.) and added into reverse osmosis system fish water at 13 final concentrations.

    Techniques: Activity Assay, Inhibition, Control